Testicular Rejuvenation Using Platelet-Rich Plasma(PRP)
About 30%-50% of cases of infertility worldwide is associated to the male factor. Testicular failure / Non obstructive Azoospermia has always been the major challenge with the male factor. It is the failure of the testis to start/initiate the process of spermatogenesis. In the past, patients with this condition can only achieve conception by means of assisted reproduction and in most cases they rely on options of donor sperm or adoption. The discovery of the effect of platelets in regenerative therapy and its application in testicular rejuvenation has given hope to patients with this condition and has helped in restoring the pride of most men.
What is platelet-rich plasma?
Platelet-rich plasma (PRP) is a unique autologous agent derived from blood that is rich in growth factors, cytokines, and hormones. When platelets get activated, numerous biologically active proteins that stimulate cell proliferation, growth and differentiation are released. Activated platelets also release various types of growth factors like
- Platelet-Derived growth factor (PDGF)
- Transforming growth factor (TGF)
- Fibroblast growth factor (FGF)
- Epidermal growth factor (EGF)
- Insulin like growth factor (IGF-1)
- Hepatocytes growth factor (HGF)
PRP with its rich growth factor composition, has been already proven beneficial in improving the structural and functional impairment of the testis.
Diagnosis Of Testicular Failure/ Non Obstructive Azoospermia
The diagnosis is established on the basis of at least two semen analysis evaluation done at separate occasions followed by detailed history of the patient which includes:
- General health
- Sexual health
- Exposure to surgery, drugs, infection, radiation e.t.c.
- Physical examination (Genital & local examination for detection of signs of Klinefelter syndrome, testicular atrophy and absence of vas deference
- Hormonal investigation including FSH, LH, PROLACTIN and TESTOSTERONE.
Testicular Rejuvenation Using PRP
PRP is prepared from fresh whole blood which is collected from a pheripheral vein, stored in either sodium citrate, or Acid Citrate Dextrose solution (ACD-A) anticoagulant and processed to increase platelets by separating various blood components.
Under sedation, the patient undergo PRP intra-testicular injection with 1ml in each testicle using fine needle.
2 to 4 months following testicular rejuvenation using PRP, TESA (Testicular sperm aspiration) or Semen analysis can be repeated to confirm the increase in sperm count, motility and morphology.
Contact us at Alps hospitals and diagnostics to set up a consultation with a member of our professional and experienced Alps hospital medical staff if you would like more information about this form of fertility treatment. We at Alps hospitals remains committed to walking this journey with you until you welcome your baby.